NeuroMotor PenTM Report

Published

March 15, 2023

Parkinson’s Disease Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC043
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-08 14:34
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

old pacient

tbl Madopar 250mg 3x1/4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 11, 'TP': 22, 'FP': 19}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 13.0044
timePerCircleCoV 0.155099
timePerCircleSlope -0.0440362
meanError 1.11832
tremorFreq 6.25
tremorRelPower 25.2716
tremorGyroAmpMean 0.0665598
tremorGyroAmpSlope -0.000545087
tremorGyroAmpCoV 0.368593
tremorCoordAmpMean 0.0655033
tremorCoordAmpSlope 0.00112261
tremorCoordAmpCoV 0.310369
tremorAccAmpMean 0.0908445
tremorAccAmpSlope 0.000214645
tremorAccAmpCoV 0.146408
tremorPcRelVar 0.816955
tremorPcX -0.644136
tremorPcY -0.764911

Circle Segment 1

Duration 17.44 s, Accuracy Estimate 1.423 (lower is better)

Circle Segment 2

Duration 14.0 s, Accuracy Estimate 1.321 (lower is better)

Circle Segment 3

Duration 12.84 s, Accuracy Estimate 1.108 (lower is better)

Circle Segment 4

Duration 12.0 s, Accuracy Estimate 1.215 (lower is better)

Circle Segment 5

Duration 14.32 s, Accuracy Estimate 1.029 (lower is better)

Circle Segment 6

Duration 12.36 s, Accuracy Estimate 0.9 (lower is better)

Circle Segment 7

Duration 11.4 s, Accuracy Estimate 0.913 (lower is better)

Circle Segment 8

Duration 10.8 s, Accuracy Estimate 0.869 (lower is better)

Circle Segment 9

Duration 11.88 s, Accuracy Estimate 1.287 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 39.8667
timePerSpiralCoV 0.146642
timePerSpiralSlope 0.00728141
meanError 2.74581
tremorFreq 5.66406
tremorRelPower 30.5118
tremorGyroAmpMean 0.115861
tremorGyroAmpSlope 0.00131842
tremorGyroAmpCoV 0.395017
tremorCoordAmpMean 0.104864
tremorCoordAmpSlope 0.000621103
tremorCoordAmpCoV 0.322571
tremorAccAmpMean 0.122092
tremorAccAmpSlope 0.000229724
tremorAccAmpCoV 0.193677
tremorPcRelVar 0.774727
tremorPcX -0.724278
tremorPcY -0.689508

Spiral Segment 1

Duration 43.76 s, Accuracy Estimate 3.086 (lower is better)

Spiral Segment 2

Duration 29.88 s, Accuracy Estimate 4.86 (lower is better)

Spiral Segment 3

Duration 40.12 s, Accuracy Estimate 2.159 (lower is better)

Spiral Segment 4

Duration 47.2 s, Accuracy Estimate 2.171 (lower is better)

Spiral Segment 5

Duration 39.84 s, Accuracy Estimate 1.761 (lower is better)

Spiral Segment 6

Duration 38.4 s, Accuracy Estimate 2.438 (lower is better)

Elel

eDurationMean 0.519595
eDurationStd 0.0970637
eDurationStdnorm 0.186807
eDurationMedian 0.495
eDurationQuartdelta 0.13375
eDurationQuartdeltanorm 0.270202
eDurationKurt 2.32427
eDurationTrenddiff -0.135
eDurationTrendratio 0.769231
eWidthMean 4.98673
eWidthStd 1.46739
eWidthStdnorm 0.29426
eWidthMedian 4.68
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.325
eWidthKurt 2.80977
eWidthTrenddiff -0.351
eWidthTrendratio 0.928571
eHeightMean 8.55681
eHeightStd 2.15652
eHeightStdnorm 0.252024
eHeightMedian 8.19
eHeightQuartdelta 2.48625
eHeightQuartdeltanorm 0.303571
eHeightKurt 3.64619
eHeightTrenddiff -1.521
eHeightTrendratio 0.835443
eAspectMean 0.598027
eAspectStd 0.156533
eAspectStdnorm 0.26175
eAspectMedian 0.567164
eAspectQuartdelta 0.144805
eAspectQuartdeltanorm 0.255314
eAspectKurt 3.43953
eAspectTrenddiff 0.0578284
eAspectTrendratio 1.10873
eSlantMean -0.261194
eSlantStd 0.207543
eSlantStdnorm -0.794596
eSlantMedian -0.253968
eSlantQuartdelta 0.275527
eSlantQuartdeltanorm -1.08489
eSlantKurt 2.80316
eSlantTrenddiff 0.0716748
eRtopMean 0.461835
eRtopStd 0.166259
eRtopStdnorm 0.359996
eRtopMedian 0.486486
eRtopQuartdelta 0.232005
eRtopQuartdeltanorm 0.476898
eRtopKurt 2.52213
eRtopTrenddiff 0.0621166
eRbotMean 0.968458
eRbotStd 0.438657
eRbotStdnorm 0.452944
eRbotMedian 0.882353
eRbotQuartdelta 0.444143
eRbotQuartdeltanorm 0.503362
eRbotKurt 5.68418
eRbotTrenddiff -0.285454
eRrightMean 0.694376
eRrightStd 0.140323
eRrightStdnorm 0.202086
eRrightMedian 0.692308
eRrightQuartdelta 0.180639
eRrightQuartdeltanorm 0.260923
eRrightKurt 3.06535
eRrightTrenddiff 0.0357931
eRleftMean 0.547569
eRleftStd 0.145732
eRleftStdnorm 0.266143
eRleftMedian 0.516484
eRleftQuartdelta 0.179169
eRleftQuartdeltanorm 0.346902
eRleftKurt 2.69997
eRleftTrenddiff -0.003996
lDurationMean 0.682375
lDurationStd 0.121228
lDurationStdnorm 0.177655
lDurationMedian 0.6575
lDurationQuartdelta 0.16
lDurationQuartdeltanorm 0.243346
lDurationKurt 3.20131
lDurationTrenddiff -0.115
lDurationTrendratio 0.844068
lWidthMean 8.15197
lWidthStd 1.90534
lWidthStdnorm 0.233727
lWidthMedian 8.0145
lWidthQuartdelta 3.042
lWidthQuartdeltanorm 0.379562
lWidthKurt 2.06102
lWidthTrenddiff -0.0585
lWidthTrendratio 0.992754
lHeightMean 20.9196
lHeightStd 2.5788
lHeightStdnorm 0.123272
lHeightMedian 21.0015
lHeightQuartdelta 3.5685
lHeightQuartdeltanorm 0.169916
lHeightKurt 2.40924
lHeightTrenddiff -1.5795
lHeightTrendratio 0.926431
lAspectMean 0.389548
lAspectStd 0.0755393
lAspectStdnorm 0.193915
lAspectMedian 0.387788
lAspectQuartdelta 0.101025
lAspectQuartdeltanorm 0.260517
lAspectKurt 2.31691
lAspectTrenddiff 0.00910826
lAspectTrendratio 1.02388
lSlantMean -0.11835
lSlantStd 0.170249
lSlantStdnorm -1.43852
lSlantMedian -0.124625
lSlantQuartdelta 0.214275
lSlantQuartdeltanorm -1.71936
lSlantKurt 3.39495
lSlantTrenddiff 0.0609902
lRtopMean 0.582288
lRtopStd 0.173231
lRtopStdnorm 0.2975
lRtopMedian 0.569952
lRtopQuartdelta 0.251025
lRtopQuartdeltanorm 0.440432
lRtopKurt 2.27463
lRtopTrenddiff 0.140867
lRbotMean 0.946061
lRbotStd 0.390626
lRbotStdnorm 0.412897
lRbotMedian 0.898247
lRbotQuartdelta 0.475426
lRbotQuartdeltanorm 0.529282
lRbotKurt 4.52663
lRbotTrenddiff -0.0921219
lRrightMean 0.766424
lRrightStd 0.128617
lRrightStdnorm 0.167815
lRrightMedian 0.786798
lRrightQuartdelta 0.155861
lRrightQuartdeltanorm 0.198095
lRrightKurt 3.82052
lRrightTrenddiff 0.0608221
lRleftMean 0.578705
lRleftStd 0.121769
lRleftStdnorm 0.210417
lRleftMedian 0.588264
lRleftQuartdelta 0.155025
lRleftQuartdeltanorm 0.26353
lRleftKurt 3.90799
lRleftTrenddiff 0.0201636

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.738522
sumTouchScores 5.90818
meanMovementTime 2.11214
numTouches 8
undershootPercentage 0
overshootPercentage 37.5

FITTS Long Modified

meanTouchScore 0.554686
sumTouchScores 4.99217
meanMovementTime 2.02062
numTouches 9
undershootPercentage 11.1111
overshootPercentage 77.7778

ZigZag

numZigzags 5
timePerZigzagMean 46.056
timePerZigzagCoV 0.100978
timePerZigzagSlope 0.0265763
meanError 2.83844
tremorFreq 6.05469
tremorRelPower 23.9541
tremorGyroAmpMean 0.108606
tremorGyroAmpSlope -0.000556762
tremorGyroAmpCoV 0.518672
tremorCoordAmpMean 0.147559
tremorCoordAmpSlope -0.000267194
tremorCoordAmpCoV 0.388621
tremorAccAmpMean 0.115452
tremorAccAmpSlope -0.000179805
tremorAccAmpCoV 0.369984
tremorPcRelVar 0.686647
tremorPcX -0.904626
tremorPcY -0.426207

ZigZag Segment 1

Duration 43.36 s, Accuracy Estimate 3.024 (lower is better)

ZigZag Segment 2

Duration 44.48 s, Accuracy Estimate 2.736 (lower is better)

ZigZag Segment 3

Duration 50.4 s, Accuracy Estimate 2.963 (lower is better)

ZigZag Segment 4

Duration 40.64 s, Accuracy Estimate 2.704 (lower is better)

ZigZag Segment 5

Duration 51.4 s, Accuracy Estimate 2.765 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.504
timePerZigzagCoV 0.067328
timePerZigzagSlope 0.0135087
zigzagHeightMean 74.2478
zigzagHeightCoV 0.0250473
zigzagHeightSlope -0.00923635
meanError 0.0410781
tremorFreq 5.46875
tremorRelPower 33.2189
tremorGyroAmpMean 0.0918895
tremorGyroAmpSlope 0.00334749
tremorGyroAmpCoV 0.300081
tremorCoordAmpMean 0.257218
tremorCoordAmpSlope 0.000540914
tremorCoordAmpCoV 0.894281
tremorAccAmpMean 0.113257
tremorAccAmpSlope 0.00314889
tremorAccAmpCoV 0.246208
tremorPcRelVar 0.881587
tremorPcX -0.0331878
tremorPcY -0.999449

ZigZag Offset Segment 1

Duration 21.72 s, Accuracy Estimate 0.049 (lower is better)

ZigZag Offset Segment 2

Duration 23.72 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 21.4 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 21.16 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 5

Duration 24.52 s, Accuracy Estimate 0.059 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7362334751774249}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9155349489646145}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}